Advances and Challenges in the Investigation of Metastasis in Diffuse Large B-Cell Lymphoma

Abstract

Diffuse Large B-cell Lymphoma (DLBCL), an aggressive cancer of the B cells, is the most common pathological type of Non-hodgkin's Lymphoma (NHL), and the typical heterogeneity of the disease is due to metastasis, which indicates a poor prognosis. Currently, the key mechanism of metastasis remains largely unknown, and research focus on the same in DLBCL. Recent studies have focused on the role of Mesenchymal-epithelial Transition (MET) and Epithelial- mesenchymal Transition (EMT), the Extracellular Matrix (ECM), chemokines, cancer stem cells, and non-coding RNAs in DLBCL. Here, we have summarised the advances and challenges in the investigation of metastasis in DLBCL and attempted to reveal the potential targets that can improve patient survival.

Keywords: DLBCL; ECM; EMT and MET; Metastasis; cancer stem cells; chemokines; non-coding RNA.