Evaluation of the effects of the systemic proton pump inhibitor-omeprazole on periimplant bone regeneration and osseointegration: An experimental study

Mehmet Gul; Serkan Dundar; Alihan Bozoglan; Erhan Cahit Ozcan; Samet Tekin; Tuba Talo Yildirim; Necmettin Karasu; Muhammet Bahattin Bingul

doi:10.1016/j.jobcr.2022.04.006

Evaluation of the effects of the systemic proton pump inhibitor-omeprazole on periimplant bone regeneration and osseointegration: An experimental study

J Oral Biol Craniofac Res. 2022 May-Jun;12(3):381-384. doi: 10.1016/j.jobcr.2022.04.006. Epub 2022 May 10.

Authors

Mehmet Gul¹, Serkan Dundar², Alihan Bozoglan², Erhan Cahit Ozcan³, Samet Tekin⁴, Tuba Talo Yildirim², Necmettin Karasu⁵, Muhammet Bahattin Bingul⁶

Affiliations

¹ Sanliurfa Harran University, Department of Periodontology, Faculty of Dentistry, Sanliurfa, Turkiye.
² Firat University, Department of Periodontology, Faculty of Dentistry, Elazig, Turkiye.
³ Firat University, Department of Esthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, Elazig, Turkiye.
⁴ Firat University, Department of Protetic Dentistry, Faculty of Dentistry, Elazig, Turkiye.
⁵ Afyonkarahisar Health Sciences University, Department of Esthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, Afyonkarahisar, Turkiye.
⁶ Sanliurfa Harran University, Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Sanliurfa, Turkiye.

Abstract

Objective: Investigations of the effects of proton pump inhibitors (PPIs) on bone healing have revealed that they affect bone regeneration negatively. The exact mechanism by which this adverse effect on bone tissue is not known. The aim of this study is to biomechanic and biochemical investigation of the effects of the PPIs on guided periimplant bone regeneration.

Material & methods: Spraque dawley rats were divided controls (n = 8): there is no treatment during 8 week experimental period, PPI- Dosage 1 (n = 8) and Dosage 2 (n = 8): 5 mg/kg and 10 mg/kg omeprazol applied 3 times in a week with oral gavage during 8 weeks respectfully. Bone defects created half of the implant length circumferencial after implant insertion and defects filled with bone grafts. After experimental period the rats sacrified and implants with surrounding bone tissues were removed to reverse torque analysis (Newton), blood samples collected to biochemical analysis (glucose, AST, ALT, ALP, urea, creatinin, calcium, P).

Results: Biomechanic reverse torque values did not revealed any statistical differences between the groups (P > 0,05).

Conclusion: According the biomechanical and biochemical parameters PPIs does not effect the periimplant guided bone regeneration.

Keywords: Guided bone regeneration; Omeprazole; Osseointegration; Proton pump inhibitors; Tibial bone.