In-situ construction of hollow double-shelled CoSx@CdS nanocages with prominent photoelectric response for highly sensitive photoelectrochemical biosensor

Shuai Cheng; Min Chen; Zengyao Zheng; Jianying Yang; Jingjun Peng; Hangui Yang; Delun Zheng; Yaowen Chen; Wenhua Gao

doi:10.1016/j.aca.2022.339881

In-situ construction of hollow double-shelled CoS_x@CdS nanocages with prominent photoelectric response for highly sensitive photoelectrochemical biosensor

Anal Chim Acta. 2022 Jun 8:1211:339881. doi: 10.1016/j.aca.2022.339881. Epub 2022 May 3.

Authors

Shuai Cheng¹, Min Chen², Zengyao Zheng³, Jianying Yang³, Jingjun Peng⁴, Hangui Yang⁵, Delun Zheng⁴, Yaowen Chen⁴, Wenhua Gao⁶

Affiliations

¹ Department of Chemistry and Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong, 515063, PR China; Shantou Food Inspection and Testing Center, Shantou, Guangdong, 515041, PR China.
² Shantou Food Inspection and Testing Center, Shantou, Guangdong, 515041, PR China.
³ Guangdong Shantou Supervision Testing Institute of Quality & Measuring, Shantou, Guangdong, 515041, PR China.
⁴ Department of Chemistry and Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong, 515063, PR China.
⁵ Department of Chemistry and Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong, 515063, PR China; Guangdong Wuyan Testing Technology Co. Ltd, Chaozhou, Guangdong, 510665, PR China.
⁶ Department of Chemistry and Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, Shantou, Guangdong, 515063, PR China. Electronic address: whgao@stu.edu.cn.

PMID: 35589222
DOI: 10.1016/j.aca.2022.339881

Abstract

In this work, we demonstrate a delicate design and construction of hollow double-shelled CoS_x@CdS nanocages (CoS_x@CdS-HDSNCs) as an efficient and stable photoactive material of photoelectrochemical (PEC) biosensor for detecting cardiac troponin I (cTnI). The novel self-templated strategy started with ZIF-67, in which two distinct sulfide semiconductors were integrated into a hollow heterojunction with uniform interfacial contacts after sequential anion and cation exchange. The unique thin double shell hollow structure, suitable energy band arrangement and stable electron transmission vastly enhanced the ability of light capture and photogenerated electron-hole separation of biosensor. Subsequently, the photoelectric performance of the heterojunction was further enhanced by the deposition of Au nanoparticles (NPs) on the surface of the CoS_x@CdS-HDSNCs resulting in surface plasmon resonance (SPR) effect. Based on the excellent CoS_x@CdS-HDSNCs, the biosensor exhibits a high sensitivity for detection of cTnI with a wide linear range (0.00016-16 ng mL^-1) and low detection limit (38.6 fg mL^-1). Besides, the PEC biosensor exhibited satisfactory stability, selectivity, and reproducibility in human serum. And more importantly, our work may provide more unique inspiration for the design of photoactive materials for the future PEC sensing applications.

Keywords: Cardiac troponin I; CoS(x)@CdS nanocages; Hollow double-shelled structure; Photoelectrochemical biosensor.

MeSH terms

Biosensing Techniques* / methods
Cadmium Compounds / chemistry*
Cobalt / chemistry*
Electrochemical Techniques
Gold / chemistry
Humans
Limit of Detection
Metal Nanoparticles* / chemistry
Nanostructures
Reproducibility of Results
Sulfides / chemistry*
Troponin I

Substances

Cadmium Compounds
Sulfides
Troponin I
cadmium sulfide
Cobalt
Gold
cobaltous sulfide