Tissue distribution of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) in mice via oral exposure

Longfei Zhou; Sisi He; Yali Shi; Yaqi Cai; Chunhui Zhang

doi:10.1016/j.envint.2022.107289

Tissue distribution of sodium p-perfluorous nonenoxybenzene sulfonate (OBS) in mice via oral exposure

Environ Int. 2022 Jul:165:107289. doi: 10.1016/j.envint.2022.107289. Epub 2022 May 11.

Authors

Longfei Zhou¹, Sisi He², Yali Shi³, Yaqi Cai⁴, Chunhui Zhang⁵

Affiliations

¹ State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China.
² State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; School of Chemical & Environmental Engineering, China University of Mining and Technology-Beijing, Beijing 100083, China.
³ State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China. Electronic address: shiyali@rcees.ac.cn.
⁴ State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China; School of Environment, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China; Institute of Environment and Health, Jianghan University, Wuhan 430056, China.
⁵ School of Chemical & Environmental Engineering, China University of Mining and Technology-Beijing, Beijing 100083, China.

PMID: 35588675
DOI: 10.1016/j.envint.2022.107289

Abstract

Environmental risks caused by emerging per- and polyfluoroalkyl substances (PFASs) have attracted increasing attention. As an important substitute for perfluorooctane sulfonate (PFOS), sodium p-perfluorous nonenoxybenzene sulfonate (OBS) is widely used as a firefighting foam additive and oil recovery agent in China. This study reported the tissue distribution of OBS in KM mice that were administered a dose of OBS at 10 µg/day via daily oral gavage for 7, 14, or 28 days. During exposure, gender-based differences were observed in body weight changes and tissue distribution of OBS. Liver exhibited the highest concentrations (males: 12.57 ± 1.80 µg/g; females: 11.80 ± 5.32 µg/g) and tissue/blood ratios and contributed more than 50% to the whole-body burden of OBS in both male and female mice, showing its ability to enrich PFASs. Furthermore, there were certain differences in the distribution characteristics of the three OBS isomers. Based on its bioaccumulation potential and widespread use, further studies are required on the human exposure risks of OBS.

Keywords: Mice; OBS; Oral gavage; Tissue distribution.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkanesulfonates
Alkanesulfonic Acids*
Animals
Bioaccumulation
Female
Fluorocarbons* / toxicity
Male
Mice
Sodium
Tissue Distribution

Substances

Alkanesulfonates
Alkanesulfonic Acids
Fluorocarbons
Sodium