Understanding people's practices, knowledge and perceptions of the use of fire and fire regimes can inform fire management plans that could contribute to savanna conservation and sustainable management. We investigated the frequency of fire use, control and perceptions of fire regimes for selected livelihood and socio-cultural activities in six districts in the Guinea savanna of Ghana. The six districts were selected to have a good representation of fire prone areas in the region based on fire frequency data obtained from the CSIR Meraka Institute, South Africa. A multiple regression analysis showed that people's use of fire for the selected socio-cultural activities from district, occupation, gender, age and ethnic group significantly predicted fire use for the activities R2 = 0.043, F (5,498) = 5.43, p < 0.000. Age and occupation added significantly to the use of fire. The study revealed that the majority of respondents (83%) across the study districts used fire once a year for at least one of the following activities: land preparation, weed/pest control, burning postharvest stubble, bush clearing around homesteads, firebreaks, charcoal burning and hunting. The study also showed a higher frequency of fire use for land preparation for cropping than for the other activities. Less than a fifth of the respondents (17%) indicated that they do not use fire for any of the selected activities. The majority of respondents (65%) mentioned that they controlled their use of fire to prevent destruction to property or injuring humans. The study revealed a higher frequency of fire use in the dry season for land preparation for cropping. However, respondents rated season of burning as the most important attribute, with little attention to the other attributes of a fire regime, contrary to what is theoretically recognized. Understanding traditional fire use practices in terms of how to regulate the mix of frequency, intensity/severity, season, size and type of fire for these and other socio-cultural purposes could help to mitigate and/or manage bushfires in West African savannas and enhance savanna conservation and management. Hence, the need to better understand people's knowledge and perceptions of fire regimes in fire assisted socio-cultural practices in West Africa.