A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders

Soudeh Ghafouri-Fard; Tayyebeh Khoshbakht; Bashdar Mahmud Hussen; Hazha Hadayat Jamal; Mohammad Taheri; Mohammadreza Hajiesmaeili

doi:10.3389/fonc.2022.870996

A Comprehensive Review on Function of miR-15b-5p in Malignant and Non-Malignant Disorders

Front Oncol. 2022 May 2:12:870996. doi: 10.3389/fonc.2022.870996. eCollection 2022.

Authors

Soudeh Ghafouri-Fard¹, Tayyebeh Khoshbakht², Bashdar Mahmud Hussen^{3

4}, Hazha Hadayat Jamal⁵, Mohammad Taheri^{6

7}, Mohammadreza Hajiesmaeili^{8

9}

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
⁴ Center of Research and Strategic Studies, Lebanese French University, Erbil, Iraq.
⁵ Department of Biology, College of Education, Salahaddin University, Erbil, Iraq.
⁶ Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁷ Institute of Human Genetics, Jena University Hospital, Jena, Germany.
⁸ Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁹ Critical Care Fellowship, Department of Anesthesiology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

miR-15b-5p is encoded by MIR15B gene. This gene is located on cytogenetic band 3q25.33. This miRNA participates in the pathogenesis of several cancers as well as non-malignant conditions, such as abdominal aortic aneurysm, Alzheimer's and Parkinson's diseases, cerebral ischemia reperfusion injury, coronary artery disease, dexamethasone induced steatosis, diabetic complications and doxorubicin-induced cardiotoxicity. In malignant conditions, both oncogenic and tumor suppressor impacts have been described for miR-15b-5p. Dysregulation of miR-15b-5p in clinical samples has been associated with poor outcome in different kinds of cancers. In this review, we discuss the role of miR-15b-5p in malignant and non-malignant conditions.

Keywords: biomarker; cancer; expression; malignance; miR-15b-5p.

Publication types

Review