Correlation Between Angiotensin Receptor Type 1 Polymorphisms and Atherosclerotic Cerebral Infarction Risk

Linfa Chen; Ying Wang; Yajun Wang; Shaoting Huang; Zhaochun Wu; Jiawen He; Wangtao Zhong; Bin Zhao; Guoda Ma; You Li

doi:10.2147/PGPM.S364648

Correlation Between Angiotensin Receptor Type 1 Polymorphisms and Atherosclerotic Cerebral Infarction Risk

Pharmgenomics Pers Med. 2022 May 11:15:477-485. doi: 10.2147/PGPM.S364648. eCollection 2022.

Authors

Linfa Chen^#^{1

2}, Ying Wang^#^{1

3}, Yajun Wang^#⁴, Shaoting Huang^{1

3}, Zhaochun Wu^{1

3}, Jiawen He^{1

3}, Wangtao Zhong³, Bin Zhao^{1

3}, Guoda Ma^{1

4}, You Li^{1

5}

Affiliations

¹ Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People's Republic of China.
² Department of Neurology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, Guangdong, 516002, People's Republic of China.
³ Department of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People's Republic of China.
⁴ Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Shunde, Guangdong, 528300, People's Republic of China.
⁵ Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People's Republic of China.

^# Contributed equally.

Abstract

Background: Emerging evidences suggest that the angiotensin receptor type 1 (AT1R) contributes heavily to the pathogenesis of atherosclerotic cerebral infarction (ACI). Herein, we examined a potential link between AT1R gene polymorphisms and ACI risk among a Southern Han Chinese population.

Methods: The rs3772616, rs275645, and rs377262 AT1R polymorphisms were genotyped in 689 ACI patients and 712 healthy controls, using the iMLDR-TM assay.

Results: The genotypic and allelic frequencies of AT1R rs3772616 differed tremendously between ACI patients and healthy controls, and the rs3772616 T allele is a risk allele for ACI. However, the rs275645 and rs377262 allelic and genotypic frequency distributions were comparable between ACI patients and controls. In addition, the G-T-T haplotype was linked to an enhanced risk of ACI. We, next, classified our study subjects based on environmental factors and revealed that the rs3772616 T allele was strongly associated with an elevated ACI risk in males, hypertensive individuals, and those over 65 years old. In addition, we observed a marked link between the rs3772616 T allele and enhanced AT1R levels.

Conclusion: Based on our research, there is a strong correlation between the AT1R rs3772616 polymorphism and enhanced ACI risk. Hence, the AT1R rs3772616 polymorphism can serve as a potential therapeutic target and bioindicator for ACI development.

Keywords: angiotensin receptor type 1; atherosclerotic cerebral infarction; case-control; polymorphism.