MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers

Zhuoying Du; Fangshun Tan; Jinlan Chen; Bei Wang; Yuling Liu; Fangnan Zhao; Yinxin Wu; Chengfu Yuan

doi:10.2174/1381612828666220516090245

MEG8: An Indispensable Long Non-coding RNA in Multiple Cancers

Curr Pharm Des. 2022;28(20):1688-1694. doi: 10.2174/1381612828666220516090245.

Authors

Zhuoying Du^{1

2}, Fangshun Tan^{1

2}, Jinlan Chen^{1

2}, Bei Wang^{1

2}, Yuling Liu^{1

2}, Fangnan Zhao^{1

2}, Yinxin Wu^{1

2}, Chengfu Yuan^{1

2}

Affiliations

¹ Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
² Medical College, China Three Gorges University, Yichang 443002, China.

PMID: 35578848
DOI: 10.2174/1381612828666220516090245

Abstract

Background: As a member of long non-coding RNAs (lncRNAs), maternally expressed gene 8 (MEG8) has been found involving in the progression of a variety of cancers and playing a regulatory role. Therefore, MEG8 may turn into a new therapeutic target for cancer in the future. The purpose of this review is to illustrate the molecular mechanism and physiological function of MEG8 in various cancers.

Methods: We retrieved and analyzed related articles about MEG8, lncRNAs, and cancers, and then summarize the pathophysiological mechanisms of MEG8 in cancer development.

Results: LncRNA MEG8 participates in various cancers progression, thus influencing the proliferation, migration, and invasion of cancers. However, the expression of MEG8 is abnormally upregulated in non-small cell lung cancer (NSCLC), pancreatic cancer (PC), liver cancer (HCC), pituitary adenoma (PA) and hemangioma (HA), and inhibited in colorectal cancer (CRC), ovarian cancer (OC) and giant cell tumor (GCT), suggesting its clinical value in cancer therapy.

Conclusion: LncRNA MEG8 is expected to be a new therapeutic target or biomarker for a wide range of cancers in the future.

Keywords: Long non-coding RNA; MEG8; molecular mechanism; ovarian cancer; pancreatic cancer; therapeutic target; tumorigenesis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Proliferation
Gene Expression Regulation, Neoplastic
Humans
Neoplasms / metabolism*
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

RNA, Long Noncoding