The structure of Crimean-Congo hemorrhagic fever virus Gc is revealed; many more still need an answer

Virol Sin. 2022 Aug;37(4):634-636. doi: 10.1016/j.virs.2022.05.003. Epub 2022 May 14.

¹ Department of Microbiology, School of Preclinical Medicine, Airforce Medical University: Fourth Military Medical University, Xi'an, 710032, China. Electronic address: virologyyw@fmmu.edu.cn.
² Department of Infectious Diseases, Tangdu Hospital, Airforce Medical University: Fourth Military Medical University, Xi'an, 710038, China.
³ Department of Microbiology, School of Preclinical Medicine, Airforce Medical University: Fourth Military Medical University, Xi'an, 710032, China; Department of Dermatology, The Eighth Medical Center of PLA General Hospital, Beijing, 100091, China.
⁴ Department of Microbiology, School of Preclinical Medicine, Airforce Medical University: Fourth Military Medical University, Xi'an, 710032, China.
⁵ Department of Microbiology, School of Preclinical Medicine, Airforce Medical University: Fourth Military Medical University, Xi'an, 710032, China. Electronic address: yflei@fmmu.edu.cn.
⁶ Department of Microbiology, School of Preclinical Medicine, Airforce Medical University: Fourth Military Medical University, Xi'an, 710032, China. Electronic address: flzhang@fmmu.edu.cn.

Abstract

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The structure of glycoprotein Gc, responsible for membrane fusion, is revealed, but many more mysteries remain.
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Why do only antibodies against Gc have neutralizing effect, but not the one against Gn?
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Why can NAbs against Gc only be protective in the animals in preventive settings, but not in the therapeutic administration?