TLR4 Gene Polymorphisms Interaction With Ascaris Infection in Severe RSV Bronchiolitis

Jefferson Antonio Buendía; Erika Fernanda Lindarte; Fernando P Polack

doi:10.3389/fped.2022.876882

TLR4 Gene Polymorphisms Interaction With Ascaris Infection in Severe RSV Bronchiolitis

Front Pediatr. 2022 Apr 27:10:876882. doi: 10.3389/fped.2022.876882. eCollection 2022.

Authors

Jefferson Antonio Buendía¹, Erika Fernanda Lindarte¹, Fernando P Polack²

Affiliations

¹ Department of Pharmacology and Toxicology, School of Medicine, Research Group in Pharmacology and Toxicology (INFARTO), Universidad de Antioquia, Medellín, Colombia.
² Fundacion Infant, Buenos Aires, Argentina.

Abstract

Introduction: The identification of gene-environment interactions allows the recognition of groups with higher risk of morbidity. This study evaluated the interaction between the presence of TLR4 gene polymorphisms and Ascaris infection with severe bronchiolitis in a tropical Colombian region.

Methods: We included all infants younger than 24 months hospitalized due to bronchiolitis in Hospital centers in the county of Rionegro, Colombia. To identify interaction between severe bronchiolitis and presence of TLR4 polymorphisms and Ascaris infection, we used log-binomial regression.

Results: Four hundred and seventeen infants were hospitalized due to bronchiolitis, of which 115 (27%) had severe bronchiolitis. In infants with respiratory syncytial virus (RSV) acute infection and positive anti-Ascaris IgE, TLR4 Asp299Gly was associated to low risk of severe bronchiolitis (OR 0.09, CI 95% 0.01-0.48). Conversely, in infants RSV negative with negative anti-Ascaris IgE, TLR4 Asp299Gly was associated with an increased risk of severe bronchiolitis (OR 14.5, CI 95% 2.2-96).

Conclusion: In our population there is an interaction between the presence of severe bronchiolitis, TLR4 Asp299Gly and Ile399Thr polymorphisms, anti-Ascaris IgE levels and RSV. This association should be evaluated in other populations to elucidate its role in the pathogenesis of severe bronchiolitis.

Keywords: Ascaris. suum; Colombia; polymorphism; respiratory syncytial virus; severe bronchiolitis.