Photoinduced Trifluoromethylation with CF3Br as a Trifluoromethyl Source: Synthesis of α-CF3-Substituted Ketones

Ransong Ma; Zhoubin Deng; Ke-Hu Wang; Junjiao Wang; Danfeng Huang; Yingpeng Su; Yulai Hu; Xiaobo Lv

doi:10.1021/acsomega.2c01241

Photoinduced Trifluoromethylation with CF₃Br as a Trifluoromethyl Source: Synthesis of α-CF₃-Substituted Ketones

ACS Omega. 2022 Apr 12;7(16):14357-14362. doi: 10.1021/acsomega.2c01241. eCollection 2022 Apr 26.

Authors

Ransong Ma¹, Zhoubin Deng¹, Ke-Hu Wang¹, Junjiao Wang¹, Danfeng Huang¹, Yingpeng Su¹, Yulai Hu^{1

2}, Xiaobo Lv³

Affiliations

¹ College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning East Road, Lanzhou 730070, P. R. China.
² State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
³ Shanghai Sinofluoro Chemicals Co., Ltd., Shanghai 201321, P. R. China.

Abstract

An efficient and novel photoinduced trifluoromethylation employing CF₃Br as a trifluoromethyl source is described. With commercially accessible fac-Ir^(III)(ppy)₃ as the catalyst, radical trifluoromethylation between O-silyl enol ether and CF₃Br occurs successfully. This method provides various α-CF₃-substituted ketones with a broad substrate scope in good yields under mild reaction conditions.