The correlation between proteoglycan 2 and neuropsychiatric systemic lupus erythematosus

Xiaoyue Qiao; Li Lu; Kangxing Zhou; Liping Tan; Xuan Liu; Jiali Ni; Yayi Hou; Jun Liang; Huan Dou

doi:10.1016/j.clim.2022.109042

The correlation between proteoglycan 2 and neuropsychiatric systemic lupus erythematosus

Clin Immunol. 2022 Jun:239:109042. doi: 10.1016/j.clim.2022.109042. Epub 2022 May 12.

Authors

Xiaoyue Qiao¹, Li Lu¹, Kangxing Zhou², Liping Tan¹, Xuan Liu¹, Jiali Ni¹, Yayi Hou³, Jun Liang⁴, Huan Dou⁵

Affiliations

¹ The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing 210093, China.
² Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
³ The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China. Electronic address: yayihou@nju.edu.cn.
⁴ Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. Electronic address: 13505193169@139.com.
⁵ The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing 210093, China. Electronic address: douhuan@nju.edu.cn.

PMID: 35568106
DOI: 10.1016/j.clim.2022.109042

Abstract

The proposed pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) mainly includes ischemia and neuroinflammation mechanisms. Protein encoded by Proteoglycan 2 (PRG2) mRNA is involved in the immune process related to eosinophils, also being found in the placenta and peripheral blood of pregnant women. We evaluated the correlation between PRG2 and NPSLE for the first time and found that PRG2 protein was overexpressed in the serum of patients with NPSLE and correlated with the SLE disease activity index (SLEDAI) subset scores of psychosis. Moreover, we investigated the correlation between hippocampal PRG2 level and hippocampally dependent learning and memory ability in MRL/lpr mice, and discovered that the number of PRG2⁺GFAP⁺ astrocytes in the cortex and hypothalamus and the number of PRG2⁺IBA-1⁺ microglia in the hippocampus and cortex significantly increased in the MRL/lpr mice. These data provided a reference for the follow-up exploration of the role of PRG2 in SLE or other diseases.

Keywords: MRL/lpr lupus mice; Neuropsychiatric systemic lupus erythematosus; Proteoglycan 2; RBANS; SLEDAI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Models, Animal
Female
Humans
Lupus Erythematosus, Systemic*
Lupus Vasculitis, Central Nervous System*
Mice
Mice, Inbred MRL lpr
Microglia / metabolism
Pregnancy
Proteoglycans / genetics
Proteoglycans / metabolism

Substances

Proteoglycans