The Road from Mouse to Human ILCs: A Perspective of Understanding the Roles of ILCs in Disease

Abstract

The chapters of this book give a comprehensive overview of the current state of knowledge of ILCs. Most of this knowledge stems from studies in mouse models. Translation to the human situation is not always straightforward because of differences between human and mouse ILCs and the microenvironments in which these ILCs are operating. Nonetheless, these mouse studies formed the basis for investigations in human diseases using state-of-the art technologies which are beginning to provide an understanding of the role of ILCs in inflammatory diseases in humans. This perspective discusses gaps in our knowledge about human ILCs and what type of studies may be done to resolve these.

Keywords: Cancer immunology; Inflammatory diseases; Innate immunity; Innate lymphoid cells.