γ-Aromatic Butenolides of Microbial Source - A Review of Their Structures, Biological Activities and Biosynthesis

Chem Biodivers. 2022 Jun;19(6):e202200208. doi: 10.1002/cbdv.202200208. Epub 2022 Jun 1.

Abstract

γ-Aromatic butenolides (γ-AB) are an important type of structures found in many bioactive microbial secondary metabolites (SMs). γ-AB refer to a group of natural products (NPs) containing five-membered (unsaturated) lactones with 3-phenyl and 4-benzyl substituents. Their wide-range biological activities have inspired pharmaceutical chemists to explore its biosynthesis mechanisms and design strategies to construct the γ-AB skeleton. Recently, there are a great deal of interesting research progress on the structures, biological activities and biosynthesis of γ-AB. This review will focus on these aspects and summarize the important achievements of γ-AB from 1975 to 2021.

Keywords: biological activities; biosynthesis; chemical constituents; review; γ-aromatic butenolides.

Publication types

  • Review

MeSH terms

  • 4-Butyrolactone* / analogs & derivatives
  • 4-Butyrolactone* / chemistry
  • 4-Butyrolactone* / pharmacology
  • Biological Products* / pharmacology
  • Lactones / chemistry

Substances

  • Biological Products
  • Lactones
  • butenolide
  • 4-Butyrolactone