A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial Characteristics

Saruchi; Manpreet Kaur; Vaneet Kumar; Ayman A Ghfar; Sadanand Pandey

doi:10.3390/polym14091911

A Green Approach for the Synthesis of Silver Nanoparticle-Embedded Chitosan Bionanocomposite as a Potential Device for the Sustained Release of the Itraconazole Drug and Its Antibacterial Characteristics

Polymers (Basel). 2022 May 7;14(9):1911. doi: 10.3390/polym14091911.

Authors

Saruchi¹, Manpreet Kaur¹, Vaneet Kumar², Ayman A Ghfar³, Sadanand Pandey⁴

Affiliations

¹ Department of Biotechnology, CT Institute of Pharmaceutical Sciences, Shahpur Campus, Jalandhar 144008, Punjab, India.
² Department of Applied Sciences, CT Institute of Engineering, Management and Technology, Shahpur Campus, Jalandhar 144623, Punjab, India.
³ Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
⁴ Department of Chemistry, College of Natural Sciences, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Gyeongbuk, Korea.

Abstract

The present research work intended to demonstrate the green synthesis of silver nanoparticles (AgNPs) using the plant extract Saccharum officinarum, and then the development of chitosan-silver (CH-Ag) bionanocomposite. The synthesized AgNPs were characterized using UV spectroscopy, Fourier transform infrared (FTIR), and transmission electron microscopy (TEM). The maximum absorption spectrum peak was observed at 420 nm, revealing the formation of AgNPs by the stem extract of S. officinarum. The AgNPs sizes were in the range of 10-50 nm. Itraconazole is an antifungal that is used as a novel drug to study its release through synthesized bionanocomposite. Different kinetic models, such as zero order, first order, Korsmeyer-Peppas, Hixson-Crowell and Higuchi, were used to study the drug release profile from the synthesized CH-Ag bionanocomposite. The first-order kinetic model showed the best fit for the drug release with the maximum regression coefficient value. The antibacterial activity of the synthesized CH-Ag bionanocomposite was examined against Bacillus cereus, Staphylococcus, and Escherichia coli, and it was shown to be efficient against these strains.

Keywords: Saccharum officinarum; antibacterial activity; bionanocomposite; chitosan; silver nanoparticles.

Grants and funding

The Authors (Saruchi and Vaneet Kumar) are thankful to the CT Group of Institutions for providing the facility to carryout this research work. The author (Ayman A. Ghfar) is grateful to the Researchers Supporting Project number (RSP-2021/407), King Saud University, Riyadh, Saudi Arabia for the financial support.