Precision medicine requires understanding how both sex and gender influence health

Nina S Stachenfeld; Carolyn M Mazure

doi:10.1016/j.cell.2022.04.012

Precision medicine requires understanding how both sex and gender influence health

Cell. 2022 May 12;185(10):1619-1622. doi: 10.1016/j.cell.2022.04.012.

Authors

Nina S Stachenfeld¹, Carolyn M Mazure²

Affiliations

¹ John B. Pierce Laboratory, New Haven, CT 06519, USA; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USA. Electronic address: nina.stachenfeld@yale.edu.
² Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA; Women's Health Research at Yale, Yale School of Medicine, New Haven, CT 06510, USA.

PMID: 35561661
DOI: 10.1016/j.cell.2022.04.012

Abstract

Progress in studying sex as a biological variable (SABV) is slow, and the influence of gendered effects of the social environment on biology is largely unknown. Yet incorporating these concepts into basic science research will enhance our understanding of human health and disease. We provide steps to move this process forward.

Keywords: SABV; cardiovascular disease; gender; sex; sex differences; women’s health.

MeSH terms

Biomedical Research*
Female
Humans
Male
Precision Medicine
Sex Characteristics
Sex Factors
Women's Health