Hyperoside: A review on its sources, biological activities, and molecular mechanisms

Phytother Res. 2022 Jul;36(7):2779-2802. doi: 10.1002/ptr.7478. Epub 2022 May 13.

Abstract

Hyperoside is a natural flavonol glycoside in various plants, such as Crataegus pinnatifida Bge, Forsythia suspensa, and Cuscuta chinensis Lam. Medical research has found that hyperoside possesses a broad spectrum of biological activities, including anticancer, anti-inflammatory, antibacterial, antiviral, antidepressant, and organ protective effects. These pharmacological properties lay the foundation for its use in treating multiple diseases, such as sepsis, arthritis, colitis, diabetic nephropathy, myocardial ischemia-reperfusion, pulmonary fibrosis, and cancers. Hyperoside is obtained from the plants and chemical synthesis. This study aims to provide a comprehensive overview of hyperoside on its sources and biological activities to provide insights into its therapeutic potential, and to provide a basis for high-quality studies to determine the clinical efficacy of this compound.

Keywords: biological activities; extraction; hyperoside; synthesis.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / pharmacology
  • Crataegus* / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Quercetin* / analogs & derivatives
  • Quercetin* / pharmacology

Substances

  • Anti-Inflammatory Agents
  • Plant Extracts
  • hyperoside
  • Quercetin