Design of a fluorogenic PNA probe capable of simultaneous recognition of 3'-overhang and double-stranded sequences of small interfering RNAs

Takaaki Tanabe; Takaya Sato; Yusuke Sato; Seiichi Nishizawa

doi:10.1039/c8ra08759h

Design of a fluorogenic PNA probe capable of simultaneous recognition of 3'-overhang and double-stranded sequences of small interfering RNAs

RSC Adv. 2018 Dec 18;8(73):42095-42099. doi: 10.1039/c8ra08759h. eCollection 2018 Dec 12.

Authors

Takaaki Tanabe¹, Takaya Sato¹, Yusuke Sato¹, Seiichi Nishizawa¹

Affiliation

¹ Department of Chemistry, Graduate School of Science, Tohoku University Sendai 980-8578 Japan satoyuu@m.tohoku.ac.jp nishi@m.tohoku.ac.jp +81-22-795-6549 +81-22-795-6552.

Abstract

We developed a new fluorescent peptide nucleic acid (PNA) probe, COT probe, capable of simultaneous recognition of 3'-overhang and double stranded sequences of target small interfering RNA (siRNA).