Nickel(ii)-catalyzed tandem C(sp2)-H bond activation and annulation of arenes with gem-dibromoalkenes

Yun Shi; Meng-Sheng Li; Fangdong Zhang; Baohua Chen

doi:10.1039/c8ra03278e

Nickel(ii)-catalyzed tandem C(sp²)-H bond activation and annulation of arenes with gem-dibromoalkenes

RSC Adv. 2018 Aug 13;8(50):28668-28675. doi: 10.1039/c8ra03278e. eCollection 2018 Aug 7.

Authors

Yun Shi¹, Meng-Sheng Li¹, Fangdong Zhang¹, Baohua Chen¹

Affiliation

¹ State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province Lanzhou 730000 P. R. China chbh@lzu.edu.cn.

Abstract

A nickel(ii)/silver(i)-catalyzed tandem C(sp²)-H activation and intramolecular annulation of arenes with dibromoalkenes has been successfully achieved, which offers an efficient approach to the 3-methyleneisoindolin-1-one scaffold. Attractive features of this system include its low cost, ease of operation, and its ability to access a wide range of isoindolinones.