Possible mechanisms and biomarkers of resistance to vismodegib in SHH medulloblastoma

Affiliations

• ¹ Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
• ² Cancer and Neurobiology Laboratory, Experimental Research Center, Clinical Hospital (CPE-HCPA), Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
• ³ Children's Cancer Institute, Porto Alegre, Brazil.
• ⁴ Department of Pediatrics, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
• ⁵ Pediatric Oncology Service, Clinical Hospital, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
• ⁶ The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
• ⁷ Developmental and Stem Cell Biology Program, The Hospital for Si ck Children, Toronto, Ontario, Canada.
• ⁸ Faculty of Health and Medicine, University of Lancaster, Lancaster, UK.