Early deviant behaviour as a dimension trait and endophenotype in schizophrenia

Johannes L Roos; Carla Kotzé

doi:10.4102/sajpsychiatry.v28i0.1747

Early deviant behaviour as a dimension trait and endophenotype in schizophrenia

S Afr J Psychiatr. 2022 Apr 29:28:1747. doi: 10.4102/sajpsychiatry.v28i0.1747. eCollection 2022.

Authors

Johannes L Roos^{1

2}, Carla Kotzé^{1

2}

Affiliations

¹ Department of Psychiatry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
² Weskoppies Psychiatric Hospital, Pretoria, South Africa.

Abstract

Background: In psychiatry, there is still a lack of objective biological diagnostic measurements. It is important to investigate measurements or symptom dimensions that can inform diagnostic assessments and allow for a more personalised approach to patients.

Aim: To discuss how early deviant behaviour (EDB) may be seen as a possible continuous symptom dimension trait and endophenotype in schizophrenia.

Methods: Conducting a commentary review by highlighting some important findings from available literature.

Results: Findings regarding EDB in schizophrenia in a South African genetic sample point towards EDB as a progressive subtype of schizophrenia, with very early onset of illness (even prior to the psychotic symptomatology) and a genetic form of illness.

Conclusion: Valuable information can be gained by enquiring into EDB and viewing it as a continuous symptom dimension trait and endophenotype during the psychiatric diagnostic interview.

Keywords: continuous symptom dimension; deviant behaviour; early onset; endophenotype; schizophrenia.

Publication types

Review