Three new tetrahydrobenzofuran derivatives from Ferula sinkiangensis K.M.Shen and their cytotoxic activities

Xianguo Yi; Zhili Li; Quanfang Zheng; Ruijuan Sang; Haili Li; Ge Gao; Qingming Qin; Nailiang Zhu

doi:10.1080/14786419.2022.2075361

Three new tetrahydrobenzofuran derivatives from Ferula sinkiangensis K.M.Shen and their cytotoxic activities

Nat Prod Res. 2023 Oct-Nov;37(20):3369-3373. doi: 10.1080/14786419.2022.2075361. Epub 2022 May 12.

Authors

Xianguo Yi¹, Zhili Li¹, Quanfang Zheng¹, Ruijuan Sang¹, Haili Li², Ge Gao¹, Qingming Qin¹, Nailiang Zhu¹

Affiliations

¹ Pharmacetical Engineering, Xinyang Agricultural and Forestry University, Xinyang, Henan Province, China.
² Animal Husbandry and Veterinary Research Institute, Henan Academy of Agricultural Sciences, Zhengzhou, Henan Province, China.

PMID: 35546105
DOI: 10.1080/14786419.2022.2075361

Abstract

Phytochemical investigation the resins of Ferula sinkiangensis K.M.Shen yielded three new tetrahydrobenzofuran derivatives named as Sinkiangensis A-C (1-3). The structures of the new compounds were elucidated by analysis of their NMR, HRMS, and ECD spectra, and the absolute configurations were established through the comparison of experimental and calculated ECD spectra. Compound 3 exhibited moderate antitumor activities against AGS cancer cell with IC₅₀ values of 15.6 µM. Moreover, assays demonstrated that compound 3 could induce AGS cancer cell apoptosis.

Keywords: AGS cell lines; Ferula sinkiangensis; cytotoxic activities; tetrahydrobenzofuran derivatives.