B lymphocyte is an important component of the human immune system and it has a role in the process of the body's specific immunity. In recent years, the research on B cells and tumor immune escape has rapidly progressed. Studies have shown that different types of B cells play different roles in tumor microenvironment through a variety of mechanisms. B cells in the tertiary lymphatic structure promote anti-tumor immunity, while regulatory B cells promote tumor immune escape. Antibody drugs targeting B cells are a promising direction for tumor immunotherapy.
B淋巴细胞是人免疫系统中的重要组成细胞，在机体发挥特异性免疫的过程中占有一席之地。近年来关于B细胞与肿瘤免疫逃逸的研究进展迅速。研究表明不同类型的B细胞在肿瘤微环境中通过多样化的机制发挥差异性作用。三级淋巴结构中的B细胞促进肿瘤的免疫杀伤作用，而调节性B细胞促进肿瘤的免疫逃逸。靶向B细胞的抗体药物是肿瘤免疫治疗潜在的新方向。.
Keywords: B cells; regulatory B cell; tertiary lymphoid structure; tumor immune escape.