KIRs mark killers suppressing autoimmunity

June-Young Koh; Eui-Cheol Shin

doi:10.1016/j.immuni.2022.04.014

KIRs mark killers suppressing autoimmunity

Immunity. 2022 May 10;55(5):735-737. doi: 10.1016/j.immuni.2022.04.014.

Authors

June-Young Koh¹, Eui-Cheol Shin²

Affiliations

¹ Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
² Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; The Center for Viral Immunology, Korea Virus Research Institute, Institute for Basic Science (IBS), Daejeon 34126, Republic of Korea. Electronic address: ecshin@kaist.ac.kr.

PMID: 35545025
DOI: 10.1016/j.immuni.2022.04.014

Abstract

Identification of regulatory CD8⁺ T cells that suppress pathological immune responses is an importunate pursuit. In a recent issue of Science, Li et al. demonstrated that human KIR⁺CD8⁺ T cells suppress autoimmunity by eliminating pathogenic CD4⁺ T cells.

Publication types

Comment

MeSH terms

Autoimmunity*
CD8-Positive T-Lymphocytes*
Humans
Receptors, KIR
T-Lymphocytes, Regulatory

Substances

Receptors, KIR