Expanding codon size

Elife. 2022 May 11:11:e78869. doi: 10.7554/eLife.78869.

Abstract

Engineering transfer RNAs to read codons consisting of four bases requires changes in tRNA that go beyond the anticodon sequence.

Keywords: DNA; E. coli; bases; biochemistry; chemical biology; directed evolution; four base codons; genetic code expansion; tRNA.

Publication types

  • Editorial

MeSH terms

  • Anticodon*
  • Codon / genetics
  • Genetic Code
  • RNA, Transfer* / genetics

Substances

  • Anticodon
  • Codon
  • RNA, Transfer