A direct cobalt-catalyzed oxidative coupling between C(sp2)-H in unactivated benzamides and C(sp3)-H in simple alkanes, ethers and toluene derivatives was explored. This protocol achieves direct C-C formation without using alkyl or aryl halide surrogates and exhibits high practicality with ample substrate scope. The method provides a new way to construct linear and five- or six-membered ring moieties in bioactive molecules.
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