Dietary Patterns and the Risk of Sarcopenia: A Systematic Review and Meta-Analysis

Mary E Van Elswyk; Lynn Teo; Clara S Lau; Christopher J Shanahan

doi:10.1093/cdn/nzac001

Dietary Patterns and the Risk of Sarcopenia: A Systematic Review and Meta-Analysis

Curr Dev Nutr. 2022 Jan 14;6(5):nzac001. doi: 10.1093/cdn/nzac001. eCollection 2022 May.

Authors

Mary E Van Elswyk¹, Lynn Teo², Clara S Lau³, Christopher J Shanahan⁴

Affiliations

¹ Van Elswyk Consulting, Inc., Clark, CO, USA.
² Teo Research Consulting, Portland, ME, USA.
³ National Cattlemen's Beef Association, a contractor to the Beef Checkoff, Washington, DC, USA.
⁴ Unleash Creatives, LLC, Reynoldsburg, OH, USA.

Abstract

The purpose of this systematic review is to examine the relationship between dietary patterns and sarcopenia using a protocol developed for use by the 2020 Dietary Guidelines Advisory Committee, and to conduct a meta-analysis to summarize the evidence. Multiple electronic databases were searched for studies investigating sarcopenia risk factors or risk of sarcopenia and dietary patterns. Eligible studies were 1) peer-reviewed controlled trials or observational trials, 2) involving adult or older-adult human subjects who were healthy and/or at risk for chronic disease, 3) comparing the effect of consumption or adherence to dietary patterns (measured as an index/score, factor or cluster analysis; reduced rank regression; or a macronutrient distribution), and 4) reported on measures of skeletal muscle mass, muscle strength, muscle performance, and/or risk of sarcopenia. Thirty-eight publications met all inclusion criteria for qualitative synthesis. Thirteen observational studies met inclusion criteria for meta-analysis. Higher adherence to a healthy dietary pattern was associated with a decreased risk of gait speed reduction (OR = 0.58; 95% CI: 0.18, 0.97). The association between healthy dietary pattern adherence and other intermediate markers or risk of sarcopenia was not statistically significant. The majority of individual studies were judged as "serious" risk of bias and analysis of the collective evidence base was suggestive of publication bias. Studies suggest a significant association between healthy dietary patterns and maintenance of gait speed with age, an intermediate marker of sarcopenia risk, but the evidence base is limited by serious risk of bias, within and between studies. Further research is needed to understand the association between healthy dietary patterns and risk of sarcopenia.

Keywords: aging; cluster analysis; diet index; diet score; dietary pattern; factor analysis; macronutrient; muscle; physical function; sarcopenia.

Publication types

Review