The Ag-promoted α-C-H arylation of alcohols

Shoufeng Wang; Shuya Xing; Yingying Zhang; Yafei Fan; Huaiqing Zhao; Jianfeng Wang; Shuxiang Zhang; Wengui Wang

doi:10.1039/c9ra09954a

The Ag-promoted α-C-H arylation of alcohols

RSC Adv. 2019 Dec 17;9(71):41847-41850. doi: 10.1039/c9ra09954a. eCollection 2019 Dec 13.

Authors

Shoufeng Wang^{1

2}, Shuya Xing¹, Yingying Zhang¹, Yafei Fan^{1

2}, Huaiqing Zhao^{1

3}, Jianfeng Wang⁴, Shuxiang Zhang^{1

2}, Wengui Wang^{1

2}

Affiliations

¹ School of Chemistry and Chemical Engineering, University of Jinan 336 West Road of Nan Xinzhuang Jinan 250022 China chm_wangwf@ujn.edu.cn chm_wangwg@ujn.edu.cn.
² Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials 336 West Road of Nan Xinzhuang Jinan 250022 China.
³ Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong 336 West Road of Nan Xinzhuang Jinan 250022 China.
⁴ Department of Respiratory Diseases, The Affiliated Hospital of Hangzhou Normal University Hangzhou Zhejiang 310015 China.

Abstract

We herein report the functionalization of α-C-H in alcohols through cross-dehydrogenative coupling reactions. Selectfluor was used as a mild oxidant. In situ-generated HF participated in the reaction and no external strong acid was necessary. A variety of heteroaryl-substituted alcohols were achieved with good yields and with good functional group tolerance.