Synthesis of benzoxazoles via an iron-catalyzed domino C-N/C-O cross-coupling reaction

Bo Yang; Weiye Hu; Songlin Zhang

doi:10.1039/c7ra13080e

Synthesis of benzoxazoles via an iron-catalyzed domino C-N/C-O cross-coupling reaction

RSC Adv. 2018 Jan 9;8(5):2267-2270. doi: 10.1039/c7ra13080e.

Authors

Bo Yang¹, Weiye Hu¹, Songlin Zhang¹

Affiliation

¹ Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University Suzhou 215123 P. R. China zhangsl@suda.edu.cn.

Abstract

An eco-friendly and efficient method has been developed for the synthesis of 2-arylbenzoxazoles via a domino iron-catalyzed C-N/C-O cross-coupling reaction. Some of the issues typically encountered during the synthesis of 2-arylbenzoxazoles in the presence of palladium and copper catalysts, including poor substrate scope and long reaction times have been addressed using this newly developed iron-catalyzed method.