Preparation of a mimetic and degradable poly(ethylene glycol) by a non-eutectic mixture of organocatalysts (NEMO) via a one-pot two-step process

S Moins; P Loyer; J Odent; O Coulembier

doi:10.1039/c9ra09781c

Preparation of a mimetic and degradable poly(ethylene glycol) by a non-eutectic mixture of organocatalysts (NEMO) via a one-pot two-step process

RSC Adv. 2019 Dec 4;9(68):40013-40016. doi: 10.1039/c9ra09781c. eCollection 2019 Dec 2.

Authors

S Moins¹, P Loyer², J Odent¹, O Coulembier¹

Affiliations

¹ Laboratory of Polymeric and Composite Materials, Center of Innovation and Research in Materials and Polymers (CIRMAP), University of Mons (UMons) Place du Parc 23 7000 Mons Belgium olivier.coulembier@umons.ac.be.
² Inserm, INRA, Univ Rennes, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR-A 1341 UMR S 1241 F-35000 Rennes France.

Abstract

A one-pot, two-step method for the preparation of degradable PEG is here presented. The full process addresses the requirements imposed by green chemistry and involves the use of a single and nontoxic non-eutectic mixture of organocatalysts. The strategy relies on the polycondensation of PEG800 after its functionalization by bio-derived 5-membered γ-butyrolactone.