3(2 H)-pyridazinone derivatives: a new scaffold for novel plant activators

Qinjie Shi; Yanxia Shi; Kang Chang; Jianqin Chen; Zhenjiang Zhao; Weiping Zhu; Yufang Xu; BaoJu Li; Xuhong Qian

doi:10.1039/c9ra06892a

3(2 H)-pyridazinone derivatives: a new scaffold for novel plant activators

RSC Adv. 2019 Nov 6;9(62):36204-36207. doi: 10.1039/c9ra06892a. eCollection 2019 Nov 4.

Authors

Qinjie Shi¹, Yanxia Shi², Kang Chang¹, Jianqin Chen¹, Zhenjiang Zhao³, Weiping Zhu¹, Yufang Xu¹, BaoJu Li², Xuhong Qian¹

Affiliations

¹ State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology Shanghai 200237 China yfxu@ecust.edu.cn.
² Institute of Vegetables and Flowers, Chinese Academy of Agricultural Science Beijing 100081 China libj@mail.caas.net.cn.
³ State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology Shanghai 200237 China.

Abstract

Due to the emergence of drug resistance, pesticide residue and environmental contamination, it is important to develop novel eco-friendly strategies to protect plants. Among them, plant activators have been gaining more and more attention. Herein, based on SHAFTS method, a new scaffold for novel plant activators was predicted and the discovery and structure-activity relationships of a series of 3(2H)-pyridazinone derivatives as novel plant activators were elucidated in detail. The vast majority of compounds exhibited excellent broad-spectrum induced resistance activity against tested diseases in vivo but no direct antimicrobial activity in vitro. Among them, compound 32 showed excellent efficacy against four pathogens and great potential as new plant activators in crop protection.