UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng

Hailin Zhu; Junli Liu; Hongqiang Lin; Ying Zhang; Na Yang; Baisong Zhou; Zhongyao Wang; Alan Chen-Yu Hsu; Jinping Liu; Pingya Li

doi:10.1039/c9ra06635g

UPLC-QTOF-MS-guided isolation of anti-COPD ginsenosides from wild ginseng

RSC Adv. 2019 Nov 26;9(66):38658-38668. doi: 10.1039/c9ra06635g. eCollection 2019 Nov 25.

Authors

Hailin Zhu¹, Junli Liu¹, Hongqiang Lin¹, Ying Zhang^{1

2}, Na Yang¹, Baisong Zhou¹, Zhongyao Wang¹, Alan Chen-Yu Hsu³, Jinping Liu^{1

4}, Pingya Li¹

Affiliations

¹ School of Pharmaceutical Sciences, Jilin University Fujin Road 1266 Changchun 130021 Jilin China liujp@jlu.edu.cn lipy@jlu.edu.cn +86-431-85619803.
² The First Hospital of Jilin University Changchun 130021 Jilin China.
³ Priority Research Centre for Healthy Lungs, Faculty of Health and Medicine, The University of Newcastle Newcastle NSW Australia.
⁴ Research Center of Natural Drug, Jilin University Changchun 130021 Jilin China.

Abstract

Four previously undescribed ginsenosides, along with five known analogues were isolated from wild ginseng by a UPLC-QTOF-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, HR-ESI-MS). The isolated compounds could significantly inhibit the cigarette smoke extract (CSE)-induced inflammatory reaction in A549 cells. The HDAC2 pathway might be involved in the protective effect against the CSE-mediated inflammatory response in A549 cells.