Azide-alkyne cycloaddition reactions in water via recyclable heterogeneous Cu catalysts: reverse phase silica gel and thermoresponsive hydrogels

Minkyung Lim; Heejin Lee; Minseok Kang; Woncheol Yoo; Hakjune Rhee

doi:10.1039/c8ra00306h

Azide-alkyne cycloaddition reactions in water via recyclable heterogeneous Cu catalysts: reverse phase silica gel and thermoresponsive hydrogels

RSC Adv. 2018 Feb 6;8(11):6152-6159. doi: 10.1039/c8ra00306h. eCollection 2018 Feb 2.

Authors

Minkyung Lim¹, Heejin Lee¹, Minseok Kang², Woncheol Yoo², Hakjune Rhee^{1

2}

Affiliations

¹ Department of Bionanotechnology, Hanyang University 55 Hanyangdaehak-ro, Sangnok-gu Ansan Gyeonggi-do 15588 South Korea.
² Department of Applied Chemistry, Hanyang University 55 Hanyangdaehak-ro, Sangnok-gu Ansan Gyeonggi-do 15588 South Korea hrhee@hanyang.ac.kr.

Abstract

Functionalized reverse phase silica gel and thermoresponsive hydrogels were synthesized as heterogeneous catalysts supports. Cu(i) and Cu(ii) catalysts immobilized onto two types of supports were prepared and characterized. The copper catalyzed azide-alkyne cycloaddition was performed in water via a one-pot reaction and yielded good results. These catalysts are air stable and reusable over multiple uses.