Tissue residency of memory CD8+ T cells matters in shaping immunogenicity of ovarian cancer

Takemasa Tsuji; Junko Matsuzaki; Kunle Odunsi

doi:10.1016/j.ccell.2022.04.008

Tissue residency of memory CD8⁺ T cells matters in shaping immunogenicity of ovarian cancer

Cancer Cell. 2022 May 9;40(5):452-454. doi: 10.1016/j.ccell.2022.04.008. Epub 2022 May 9.

Authors

Takemasa Tsuji¹, Junko Matsuzaki¹, Kunle Odunsi²

Affiliations

¹ University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA.
² University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA. Electronic address: odunsia@bsd.uchicago.edu.

PMID: 35537410
DOI: 10.1016/j.ccell.2022.04.008

Abstract

In this issue of Cancer Cell, Anadon et al. perform a multi-omics analysis of ovarian tumor infiltrating tissue-resident memory T (TRM) cells at the single-cell level that supports a differentiation model from CD103^-TCF1⁺ re-circulating T-cell precursors driven by tumor antigen recognition. CD103⁺ TRM cells play a dominant anti-tumor role in ovarian cancer.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes
Female
Humans
Immunologic Memory
Ovarian Neoplasms*

Grants and funding

P50 CA159981/CA/NCI NIH HHS/United States