Physiological Functions of FBW7 in Metabolism

Jianmei Zhang; De-Huan Kong; Xiaocheng Huang; Rongbo Yu; Yachao Yang

doi:10.1055/a-1816-8903

Physiological Functions of FBW7 in Metabolism

Horm Metab Res. 2022 May;54(5):280-287. doi: 10.1055/a-1816-8903. Epub 2022 May 9.

Authors

Jianmei Zhang^{1

2}, De-Huan Kong³, Xiaocheng Huang⁴, Rongbo Yu⁵, Yachao Yang¹

Affiliations

¹ Department of Endocrinology and Metabolism, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, China.
² Department of Geriatrics, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, China.
³ Department of Endocrinology, Taian City Central Hospital, Taian, China.
⁴ Department of Health examination, Weihai Municipal Hospital affiliated to Shandong University, Weihai, China.
⁵ Department of Geriatrics, Weihai Municipal Hospital Affiliated to Shandong University, Shangdong, China.

PMID: 35533672
DOI: 10.1055/a-1816-8903

Abstract

FBW7 is the recognition subunit of the SCF (Skp1-Cullin1-F-box proteins) E3 ubiquitin ligase complex, and it determines the specificity of the SCF substrate. SCFFBW7 is a recognized tumor suppressor because of its ability to degrade many proto-oncogenic substrates. Recent studies have shown that FBW7 plays a key role in metabolism by targeting the degradation of critical regulators involved in cellular metabolism in a ubiquitin-dependent manner. Here, we review recent studies, which highlight the important role of FBW7 in metabolism.

Publication types

Review

MeSH terms

Cell Cycle Proteins / metabolism
F-Box Proteins* / genetics
F-Box Proteins* / metabolism
F-Box-WD Repeat-Containing Protein 7 / genetics
F-Box-WD Repeat-Containing Protein 7 / metabolism
Phosphorylation
Ubiquitin-Protein Ligases* / genetics
Ubiquitin-Protein Ligases* / metabolism
Ubiquitination

Substances

Cell Cycle Proteins
F-Box Proteins
F-Box-WD Repeat-Containing Protein 7
Ubiquitin-Protein Ligases