Blocking the Metabolic Switch Toward Cytosolic 1C Flux: A Novel Therapeutic Approach for Tumors With Low SLC19A1 Expression

Pathol Oncol Res. 2022 Apr 22:28:1610337. doi: 10.3389/pore.2022.1610337. eCollection 2022.
No abstract available

Keywords: MTHFD1; One-carbon units; RPMI; SHMT1; SHMT2; TSH.

Publication types

  • Letter

MeSH terms

  • Cytosol / metabolism
  • Humans
  • Neoplasms* / metabolism
  • Reduced Folate Carrier Protein / metabolism

Substances

  • Reduced Folate Carrier Protein
  • SLC19A1 protein, human