Transdermal permeation of curcumin promoted by choline geranate ionic liquid: Potential for the treatment of skin diseases

Rodrigo Boscariol; José M Oliveira Junior; Denicezar A Baldo; Victor M Balcão; Marta M D C Vila

doi:10.1016/j.jsps.2022.01.023

Transdermal permeation of curcumin promoted by choline geranate ionic liquid: Potential for the treatment of skin diseases

Saudi Pharm J. 2022 Apr;30(4):382-397. doi: 10.1016/j.jsps.2022.01.023. Epub 2022 Feb 4.

Authors

Rodrigo Boscariol¹, José M Oliveira Junior¹, Denicezar A Baldo¹, Victor M Balcão^{1

2}, Marta M D C Vila¹

Affiliations

¹ PhageLab - Laboratory of Biofilms and Bacteriophages, University of Sorocaba, 18023-000 Sorocaba, SP, Brazil.
² Department of Biology and CESAM, University of Aveiro, Campus Universitário de Santiago, P-3810-193 Aveiro, Portugal.

Abstract

The transdermal permeation of curcumin aided by choline and geranic acid ionic liquid (CAGE-IL) was addressed as a potential treatment for skin diseases. An in-depth analysis of the effect of CAGE-IL concentration in the enhancement of transdermal permeation of curcumin was performed, and the results were modelled via nonlinear regression analysis. The results obtained showed that a low percentage of CAGE-IL (viz. 2.0%, w/w) was effective in disrupting the skin structure in a transient fashion, facilitating the passage of curcumin dissolved in it.

Keywords: Choline geranate ionic liquid; Curcumin; Psoriasis; Transdermal permeation.