Mossy cells of the dentate gyrus: Drivers or inhibitors of epileptic seizures?

Angéla Kecskés; Boldizsár Czéh; Miklós Kecskés

doi:10.1016/j.bbamcr.2022.119279

Mossy cells of the dentate gyrus: Drivers or inhibitors of epileptic seizures?

Biochim Biophys Acta Mol Cell Res. 2022 Sep;1869(9):119279. doi: 10.1016/j.bbamcr.2022.119279. Epub 2022 May 6.

Authors

Angéla Kecskés¹, Boldizsár Czéh², Miklós Kecskés³

Affiliations

¹ Department of Pharmacology and Pharmacotherapy, Medical School & Szentagothai Research Centre, Molecular Pharmacology Research Group, Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.
² Department of Laboratory Medicine, Medical School & Szentagothai Research Centre, Histology and Light Microscopy Core Facility, Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary.
³ Institute of Physiology, Medical School & Szentagothai Research Centre, Molecular Neuroendocrinology Research Group, Centre for Neuroscience, University of Pécs, H-7624 Pécs, Hungary. Electronic address: kecskes.miklos@pte.hu.

PMID: 35526721
DOI: 10.1016/j.bbamcr.2022.119279

Abstract

Mossy cells (MCs) are glutamatergic cells of the dentate gyrus with an important role in temporal lobe epilepsy. Under physiological conditions MCs can control both network excitations via direct synapses to granule cells and inhibition via connections to GABAergic interneurons innervating granule cells. In temporal lobe epilepsy mossy cell loss is one of the major hallmarks, but whether the surviving MCs drive or inhibit seizure initiation and generalization is still a debate. The aim of the present review is to summarize the latest findings on the role of mossy cells in healthy and overexcited hippocampus.

Keywords: Dentate gyrus; Epilepsy; Granule cell; Mossy cell; hippocampus.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Epilepsy*
Epilepsy, Temporal Lobe*
Hippocampus
Humans
Mossy Fibers, Hippocampal / physiology
Seizures