Imbalance of circulating innate lymphoid cell subpopulations in patients with chronic kidney disease

Ruifeng Wang; Jingjing Zhang; Dandan Li; Guiling Liu; Yuqin Fu; Qing Li; Lei Zhang; Long Qian; Li Hao; Yiping Wang; David C H Harris; Deguang Wang; Qi Cao

doi:10.1016/j.clim.2022.109029

Imbalance of circulating innate lymphoid cell subpopulations in patients with chronic kidney disease

Clin Immunol. 2022 Jun:239:109029. doi: 10.1016/j.clim.2022.109029. Epub 2022 May 4.

Authors

Ruifeng Wang¹, Jingjing Zhang², Dandan Li², Guiling Liu², Yuqin Fu³, Qing Li⁴, Lei Zhang⁵, Long Qian⁵, Li Hao², Yiping Wang⁶, David C H Harris⁶, Deguang Wang⁷, Qi Cao⁸

Affiliations

¹ Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China; Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia; Department of Nephrology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
² Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
³ Department of Nephrology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
⁴ The Central Laboratory of Medical Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
⁵ Department of Rheumatology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
⁶ Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.
⁷ Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. Electronic address: wangdeguang@ahmu.edu.cn.
⁸ Centre for Transplant and Renal Research, Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia. Electronic address: qi.cao@sydney.edu.au.

PMID: 35525476
DOI: 10.1016/j.clim.2022.109029

Abstract

Innate lymphoid cells (ILCs) are a newly identified heterogeneous family of innate immune cells. We conducted this study to investigate the frequency of circulating ILC subsets in various chronic kidney diseases (CKD). In DN, the proportion of total ILCs and certain ILC subgroups increased significantly. Positive correlations between proportion of total ILCs, ILC1s and body mass index, glycated hemoglobin were observed in DN. In LN, a significantly increased proportion of ILC1s was found in parallel with a reduced proportion of ILC2s. The proportions of total ILCs and ILC1s were correlated with WBC count and the level of C3. In all enrolled patients, the proportion of total ILCs and ILC1s was significantly correlated with the levels of ACR and GFR. In the present study, the proportion of circulating ILC subsets increased significantly in various types of CKD and correlated with clinico-pathological features, which suggests a possible role for ILCs in CKD.

Keywords: Chronic kidney disease; Diabetic nephropathy; Innate immunity; Innate lymphoid cells; Lupus nephritis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Immunity, Innate*
Lymphocytes
Renal Insufficiency, Chronic* / metabolism