[Influence of bionic texture coronary stent on hemodynamics after implantation]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2022 Apr 25;39(2):339-346. doi: 10.7507/1001-5515.202106050.
[Article in Chinese]

Abstract

To explore the influence of bionic texture coronary stents on hemodynamics, a type of bioabsorbable polylactic acid coronary stents was designed, for which a finite element analysis method was used to carry out simulation analysis on blood flow field after the implantation of bionic texture stents with three different shapes (rectangle, triangle and trapezoid), thus revealing the influence of groove shape and size on hemodynamics, and identifying the optimal solution of bionic texture groove. The results showed that the influence of bionic texture grooves of different shapes and sizes on the lower wall shear stress region had a certain regularity. Specifically, the improvement effect of grooves above 0.06 mm on blood flow characteristics was poor, and the effect of grooves below 0.06 mm was good. Furthermore, the smaller the size is, the better the improvement effect is, and the 0.02 mm triangular groove had the best improvement effect. Based on the results of this study, it is expected that bionic texture stents have provided a new method for reducing in-stent restenosis.

为探究冠脉支架的仿生织构化处理对血流动力学的影响规律,设计一款生物可吸收聚乳酸冠脉支架,利用有限元分析方法,对三种形状(矩形、三角形和梯形)的仿生织构化的支架植入后血流流场进行仿真分析,揭示沟槽的形状和尺寸对血流动力学的影响规律,并寻求仿生织构化沟槽的最优解。结果显示,不同形状和尺寸的仿生织构化沟槽,对低壁面剪应力区域的影响具有一定的规律性,0.06 mm以上的沟槽对血流流动特性的影响较小,而0.06 mm以下的沟槽对血流流动特性的影响较显著,且随着尺寸的减小影响效果越好,其中0.02 mm的三角形沟槽在研究的所有模型中的影响效果最好。通过本文研究结果,期望仿生织构化支架结构能为降低支架内再狭窄提供一种新方法。.

Keywords: Bionic texture; Coronary stent; Finite element method; Hemodynamics; Wall shear stress.

MeSH terms

  • Bionics*
  • Computer Simulation
  • Coronary Vessels
  • Hemodynamics / physiology
  • Models, Cardiovascular*
  • Stents
  • Stress, Mechanical

Grants and funding

国家自然科学基金项目(12162026);内蒙古自治区科技计划项目(2020GG0024)