Cross-translational models of late-onset cognitive sequelae and their treatment in pediatric brain tumor survivors

Noor Z Al Dahhan; Elizabeth Cox; Brian J Nieman; Donald J Mabbott

doi:10.1016/j.neuron.2022.04.009

Cross-translational models of late-onset cognitive sequelae and their treatment in pediatric brain tumor survivors

Neuron. 2022 Jul 20;110(14):2215-2241. doi: 10.1016/j.neuron.2022.04.009. Epub 2022 May 5.

Authors

Noor Z Al Dahhan¹, Elizabeth Cox², Brian J Nieman³, Donald J Mabbott⁴

Affiliations

¹ Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada.
² Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada.
³ Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada; Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada.
⁴ Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada; Department of Psychology, University of Toronto, Toronto, ON, Canada; Department of Psychology, Hospital for Sick Children, Toronto, ON, Canada. Electronic address: donald.mabbott@sickkids.ca.

PMID: 35523175
DOI: 10.1016/j.neuron.2022.04.009

Abstract

Pediatric brain tumor treatments have a high success rate, but survivors are at risk of cognitive sequelae that impact long-term quality of life. We summarize recent clinical and animal model research addressing pathogenesis or evaluating candidate interventions for treatment-induced cognitive sequelae. Assayed interventions encompass a broad range of approaches, including modifications to radiotherapy, modulation of immune response, prevention of treatment-induced cell loss or promotion of cell renewal, manipulation of neuronal signaling, and lifestyle/environmental adjustments. We further emphasize the potential of neuroimaging as a key component of cross-translation to contextualize laboratory research within broader clinical findings. This cross-translational approach has the potential to accelerate discovery to improve pediatric cancer survivors' long-term quality of life.

Keywords: basic research; clinical research; pediatric brain tumors; translational research.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms* / diagnostic imaging
Brain Neoplasms* / therapy
Cognition
Disease Progression
Humans
Neuroimaging
Quality of Life* / psychology
Survivors / psychology

Grants and funding

15620/CIHR/Canada