Efficient Route to Canagliflozin via Anhydroketopyranose

Org Lett. 2022 May 20;24(19):3450-3454. doi: 10.1021/acs.orglett.2c00980. Epub 2022 May 6.

Abstract

The development of an efficient route for the synthesis of Canagliflozin is reported. The anhydroketopyranose intermediate was isolated as a novel intermediate, which was used to prepare Canagliflozin API in high purity.

MeSH terms

  • Canagliflozin*
  • Diabetes Mellitus, Type 2*
  • Humans
  • Hypoglycemic Agents

Substances

  • Hypoglycemic Agents
  • Canagliflozin