Ni-catalysed deamidative fluorination of amides with electrophilic fluorinating reagents

Org Biomol Chem. 2022 May 26;20(20):4091-4095. doi: 10.1039/d2ob00519k.

Abstract

We describe here a Ni-catalysed deamidative fluorination of diverse amides with electrophilic fluorinating reagents. Different types of amides including aromatic amides and olefinic amides were well compatible, affording the corresponding acyl fluorides in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides*
  • Catalysis
  • Fluorides
  • Halogenation*
  • Indicators and Reagents

Substances

  • Amides
  • Indicators and Reagents
  • Fluorides