A Finite Element Model of Cerebral Vascular Injury for Predicting Microbleeds Location

Harry Duckworth; Adriana Azor; Nikolaus Wischmann; Karl A Zimmerman; Ilaria Tanini; David J Sharp; Mazdak Ghajari

doi:10.3389/fbioe.2022.860112

A Finite Element Model of Cerebral Vascular Injury for Predicting Microbleeds Location

Front Bioeng Biotechnol. 2022 Apr 20:10:860112. doi: 10.3389/fbioe.2022.860112. eCollection 2022.

Authors

Harry Duckworth^{1

2}, Adriana Azor^{1

2}, Nikolaus Wischmann¹, Karl A Zimmerman^{1

2}, Ilaria Tanini^{1

3}, David J Sharp^{2

4}, Mazdak Ghajari¹

Affiliations

¹ HEAD Lab, Dyson School of Design Engineering, Imperial College London, London, United Kingdom.
² The Computational, Cognitive and Clinical Neuroimaging Laboratory, Imperial College London, London, United Kingdom.
³ Industrial Engineering Department, University of Florence, Florence, Italy.
⁴ Care Research and Technology Centre, Dementia Research Institute, London, United Kingdom.

Abstract

Finite Element (FE) models of brain mechanics have improved our understanding of the brain response to rapid mechanical loads that produce traumatic brain injuries. However, these models have rarely incorporated vasculature, which limits their ability to predict the response of vessels to head impacts. To address this shortcoming, here we used high-resolution MRI scans to map the venous system anatomy at a submillimetre resolution. We then used this map to develop an FE model of veins and incorporated it in an anatomically detailed FE model of the brain. The model prediction of brain displacement at different locations was compared to controlled experiments on post-mortem human subject heads, yielding over 3,100 displacement curve comparisons, which showed fair to excellent correlation between them. We then used the model to predict the distribution of axial strains and strain rates in the veins of a rugby player who had small blood deposits in his white matter, known as microbleeds, after sustaining a head collision. We hypothesised that the distribution of axial strain and strain rate in veins can predict the pattern of microbleeds. We reconstructed the head collision using video footage and multi-body dynamics modelling and used the predicted head accelerations to load the FE model of vascular injury. The model predicted large axial strains in veins where microbleeds were detected. A region of interest analysis using white matter tracts showed that the tract group with microbleeds had 95th percentile peak axial strain and strain rate of 0.197 and 64.9 s^-1 respectively, which were significantly larger than those of the group of tracts without microbleeds (0.163 and 57.0 s^-1). This study does not derive a threshold for the onset of microbleeds as it investigated a single case, but it provides evidence for a link between strain and strain rate applied to veins during head impacts and structural damage and allows for future work to generate threshold values. Moreover, our results suggest that the FE model has the potential to be used to predict intracranial vascular injuries after TBI, providing a more objective tool for TBI assessment and improving protection against it.

Keywords: cerebral vasculature injury; cerebrovasculature; finite element model; microbleeds; microhaemorrhages; multibody simulation; traumatic brain injury.