In this study, a naphthalene Schiff-base P which serves as a dual-analyte probe for the quantitative detection of Al3+ and Mg2+ has been designed. The proposed probe showed an ''off-on'' fluorescent response toward Al3+ in ethanol-water solution (1 : 9, v/v, pH 6.3, 20 mM HEPES) over other metal ions and anions, while the detection by the probe could be switched to Mg2+ by regulating the pH from 6.3 to 9.4. The sensing mechanisms of P to Al3+/Mg2+ are attributed to inhibition of the photo-induced electron transfer (PET) process by the formation of 1 : 1 ligand-metal complexes. More importantly, the probe was applied successfully in living cells for the fluorescent cell-imaging of Al3+ and Mg2+.
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