Additional data for the mouse TRPV6 expression atlas

Philipp Wartenberg; Femke Lux; Kai Busch; Claudia Fecher-Trost; Veit Flockerzi; Gabriela Krasteva-Christ; Ulrich Boehm; Petra Weissgerber

doi:10.1016/j.dib.2022.108201

Additional data for the mouse TRPV6 expression atlas

Data Brief. 2022 Apr 22:42:108201. doi: 10.1016/j.dib.2022.108201. eCollection 2022 Jun.

Authors

Philipp Wartenberg¹, Femke Lux¹, Kai Busch¹, Claudia Fecher-Trost¹, Veit Flockerzi¹, Gabriela Krasteva-Christ², Ulrich Boehm¹, Petra Weissgerber¹

Affiliations

¹ Department of Experimental and Clinical Pharmacology and Toxicology, Center for Molecular Signaling (PZMS), Saarland University School of Medicine, Homburg, Germany.
² Institute of Anatomy and Cell Biology, Saarland University School of Medicine, Homburg, Germany.

Abstract

To identify TRPV6 expression in the whole mouse with a cellular resolution we took advantage of TRPV6-IRES-Cre knock-in mice crossed with the enhanced ROSA26-τGFP reporter line. In the resulting TRPV6-IC/eR26-τGFP animals, TRPV6-expressing cells are labeled with τGFP. Data were collected from organs prepared from fixed experimental adult and juvenile TRPV6-IC/eR26τGFP and Cre-negative eR26-τGFP control animals of both sexes. Organ cryosections from each age and sex were stained for GFP and imaged with a slide scanner. Here, we describe reporter gene expression in a large number of tissues. We also document the absence of τGFP signal in the corresponding Cre-negative control tissues, including controls for the TRPV6 expression data described in [1]. The data reported here and in [1] constitute the TRPV6 expression atlas for the mouse. Our data offer a wealth of information to enable investigation of the functional role of TRPV6 channels in different tissues.

Keywords: Calcium; Expression; Genetic labeling; TRP channels.