A contact lens promising for non-invasive continuous intraocular pressure monitoring

Yu Pang; Yuxing Li; Xuefeng Wang; Chenjie Qi; Yi Yang; Tian-Ling Ren

doi:10.1039/c8ra10257k

A contact lens promising for non-invasive continuous intraocular pressure monitoring

RSC Adv. 2019 Feb 11;9(9):5076-5082. doi: 10.1039/c8ra10257k. eCollection 2019 Feb 5.

Authors

Yu Pang^{1

2}, Yuxing Li^{1

2}, Xuefeng Wang^{1

2}, Chenjie Qi³, Yi Yang^{1

2}, Tian-Ling Ren^{1

2}

Affiliations

¹ Institute of Microelectronics, Tsinghua University 100084 Beijing China rentl@tsinghua.edu.cn.
² Beijing National Research Center for Information Science and Technology (BNRist), Tsinghua University 100084 Beijing China.
³ School of Applied Science, Beijing Information Science & Technology University 100192 Beijing China.

Abstract

Intraocular pressure (IOP) is the key indicator to assess the risk for and status of glaucoma patients, and medication at high IOP values slows down exacerbation of glaucoma. However, the IOP value is subject to circadian variation and cannot be measured continuously in clinical practice. Herein, we have fabricated a contact lens with a Wheatstone bridge circuit for non-invasive monitoring of IOP. A metal electrode has been used as a strain gauge to measure the weak deformation of the eyeball caused by IOP variation. Tests on a model eye indicate that the contact lens exhibits a high sensitivity of 20 μV mmHg^-1 and excellent dynamic cycling performance at different speeds of IOP variation. These results demonstrate that the contact lens sensor is promising for continuous IOP monitoring of glaucoma disease, regardless of the posture and activities of the patient.