Determinant of Osteopontin Levels in Microvascular Complications in Patients with Diabetes

Shaik Sarfaraz Nawaz; Khalid Siddiqui; Muhammad Mujammami; Obeed Alotaibi; Saud Sulaiman Alanazi; Mohamed Rafiullah

doi:10.2147/IJGM.S354220

Determinant of Osteopontin Levels in Microvascular Complications in Patients with Diabetes

Int J Gen Med. 2022 Apr 27:15:4433-4440. doi: 10.2147/IJGM.S354220. eCollection 2022.

Authors

Shaik Sarfaraz Nawaz^#¹, Khalid Siddiqui^#¹, Muhammad Mujammami^{1

2

3}, Obeed Alotaibi², Saud Sulaiman Alanazi¹, Mohamed Rafiullah¹

Affiliations

¹ Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
² University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia.
³ Division of Endocrinology, Department of Medicine, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.

^# Contributed equally.

Abstract

Background: Osteopontin (OPN) is a 44-kDa multifunctional protein and has a diverse role in biomineralization, tissue remodeling, and chronic inflammation. However, its role in type 2 diabetes (T2D) patients with microvascular complications is not clear. Therefore, the present study aimed to investigate the role of OPN in T2D patients with microvascular complications.

Methods: A total of 324 type 2 diabetes patients in the age group of 38-66 years were included in this study; 249 T2D patients were diagnosed with microvascular complications. OPN was measured using an enzyme-linked immunosorbent assay kit. Clinical data, such as age, gender, diabetes duration, systolic blood pressure, diastolic blood pressure, were measured. Correlation between OPN levels with different clinical parameters was evaluated.

Results: In patients with microvascular complications, OPN levels were significantly higher than those without microvascular complications (p < 0.05). Moreover, OPN levels were positively associated with systolic blood pressure (SBP), C-reactive protein, and albumin creatinine ratio (ACR). Multiple linear regression analysis showed that OPN levels were independently associated with C-reactive protein (p < 0.045).

Conclusion: The findings in the present study showed that OPN level was more positively associated with C-reactive protein than that with glucose metabolism in patients with microvascular complications. Thus, OPN might serve as a marker in predicting vascular disease.

Keywords: C-reactive protein; diabetes; inflammation; microvascular complication; osteopontin.

Grants and funding

The article processing charges (APC) to publish as open access will be funded by University Diabetes Center, King Saud University Medical City (KSUMC), King Saud University.