Ingenuity pathway analysis of the human cardiac cell Atlas identifies differences between right and left ventricular cardiomyocytes

Sasha Z Prisco; Felipe Kazmirczak; Thenappan Thenappan; Kurt W Prins

doi:10.1002/pul2.12011

Ingenuity pathway analysis of the human cardiac cell Atlas identifies differences between right and left ventricular cardiomyocytes

Pulm Circ. 2022 Jan 5;12(1):e12011. doi: 10.1002/pul2.12011. eCollection 2022 Jan.

Authors

Sasha Z Prisco¹, Felipe Kazmirczak¹, Thenappan Thenappan¹, Kurt W Prins¹

Affiliation

¹ Department of Medicine, Cardiovascular Division, Lillehei Heart Institute University of Minnesota Minneapolis Minnesota USA.

Abstract

Pharmaceuticals for left ventricular (LV) dysfunction do not have similar success in right ventricular (RV) failure, which may reflect biological differences between the ventricles. In this study, we performed Ingenuity Pathway Analysis of the Human Cell Atlas to understand how the transcriptomic signatures of the RV and LV differ.

Keywords: heart diseases; pulmonary heart disease; right ventricle function and dysfunction.

Abstract

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