First live birth in China after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency

Climacteric. 2022 Aug;25(4):421-424. doi: 10.1080/13697137.2022.2064215. Epub 2022 May 3.

Abstract

Objective: This article reports the first live birth after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency in China.

Methods: A patient with myelodysplastic syndrome received ovarian tissue cryopreservation before hematopoietic stem cell transplantation, and six ovarian cortex strips were thawed and transplanted into her peritoneal pocket 2 years later.

Results: Pregnancy occurred spontaneously 27 months after grafting, and a healthy girl was born at 38 weeks gestation. Until now, the child has developed normally without any major diseases.

Conclusions: We report the first live birth resulting from ovarian tissue cryopreservation and transplantation in China.

Keywords: China; Ovarian tissue cryopreservation; first; live birth; premature ovarian insufficiency; transplantation.

MeSH terms

  • Child
  • Cryopreservation / methods
  • Female
  • Fertility Preservation* / methods
  • Humans
  • Live Birth
  • Menopause, Premature*
  • Pregnancy
  • Primary Ovarian Insufficiency* / prevention & control